Humor is by far the most significant Posted on May 13, 2015May 13, 2010 by admin “Humor is by far the most significant activity of the human brain.” — Edward de Bono Author: Edward de Bono Category: humor Tags: humor, Edward de Bono Spread the love Related posts: It has always surprised me how little If I had no sense of humor, Like a welcome summer rain, humor may Analyzing humor is like dissecting a frog.